Each side can be with out their England internationals for the match as they’ve already joined up with the nationwide group for the upcoming Six Nations.
Harlequins can be with out eight gamers together with star fly-half Marcus Smith, whereas Saints can be denied the companies of seven key people.
Former membership captain Stephan Lewies will nonetheless lead out a Quins group that features Jack Walker, Joe Launchbury, Will Evans, James Chisholm and Danny Care.
“It is the Premiership champions at dwelling, we had a slim loss to them away. Each side can have a distinct look to them than they did of their European fixtures, however each side are able to some unbelievable rugby,” Wilson added.
“Being at The Stoop’s vital to us as a result of it is in entrance of our followers, we have an unbelievably good group of followers – very supportive environment at The Stoop, we felt that on Saturday night time, it made a distinction and I am relying on Friday night time they will do the identical.”