Northmore, second row Alex Coles and fly-half and captain George Ford are the one three gamers who additionally began the second Take a look at victory over the Pumas in San Juan.
Leicester’s Jack van Poortvliet will get a begin at scrum-half, whereas Sale pair Bevan Rodd and Asher Opoku-Fordjour are both aspect of Northampton’s Curtis Langdon within the entrance row.
Man Pepper makes his first England begin after two spectacular cameos off the bench in Argentina, with Harlequins pair Chandler Cunningham-South and Alex Dombrandt finishing the again row.
Bristol hooker Gabriel Oghre, who was introduced on tour after a Lions call-up for Jamie George and an harm to Theo Dan, is more likely to win his first cap off the bench, with backs Charlie Atkinson and Oscar Beard equally poised to make their Take a look at debuts.
“We all know the USA will current a tricky problem,” stated Borthwick.
“There’s been an excellent spirit within the squad all through this tour. The gamers have labored laborious for one another and pushed requirements daily. These chosen this weekend have earned their likelihood by their effort and perspective.”
England have received all seven of their earlier conferences with the USA, most not too long ago prevailing 43-29 in 2021 when, like this summer season, a raft of first-choice gamers had been away with the British and Irish Lions.
The USA suffered a 31-24 defeat by Spain in Charlotte final weekend, a loss which brought on them to slide to sixteenth on the earth rankings.
The match is being staged within the 20,000-capacity Audi Area in Washington, a venue utilized by Main League Soccer’s DC United.
Washington is one in every of 27 cities, together with Chicago, New York, Las Vegas and Los Angeles, to have expressed an curiosity in staging matches when the USA hosts the 2031 and 2033 Rugby World Cups.